Stem Cells are identical biological cells, which can make different specialized cells and can split to create more Stem Cells. They are easily found in multi-cellular organisms. In full grown organisms, Stem Cells work to mend the body system, restocking adult tissues. Adult Stem Cells are normally used in medical therapies, for example in bone marrow transplantation. Stem Cells can now be artificially grown and changed into specific cell kind with features dependable on cells of various tissues such as muscles or nerves.
In order to regenerate the function and better the quality of life, cell therapies are used in a variety of medical spheres. There are cell therapies that are life saving. Orthopedic stem cell therapy is primarily for bone grafting of skeletal flaws, managing delayed unions and non-unions, acquiring spinal arthrodesis, treating osteonecrosis and tissue engineering purposes. If you are wondering which cells should be used then you must know that stem cells are capable of duplicating and that's why change into varied cell types. Stem cells are naturally regenerative. Embryonic stem cells have the best potential to develop into various cell types whereas adult stem cells are to be more limited. For example, in an orthopedic stem cell procedure, stimulating fracture healing of cortical-cancellous bone is contrastive from using bone graft to reconstruct a defect within a bone. However, both circumstances involve complex mechanisms requiring different cell types, proteins and structures.
Orthopedic stem cell treatment for cartilage damage in Osteoarthritis centres on surgical interventions such as arthroscopic debridement, microfracture and cartilage grafting or transplant and total joint replacement. These orthopedic stem cell procedures have complications, are invasive and have a prolonged recovery time. Mesenchymal Stem Cells (MSCs) can be yielded through Bone Marrow Aspiration, increased using the patient's growth factors and then successfully implanted to boost cartilage volume in an adult human knee. Mesenchymal stem cells can also be isolated from other tissues including cord blood, peripheral blood, fallopian tube and foetal liver and lung. Because of their multi-potent capabilities, MSC's lineages have been used to regenerate bone.
An instability in bone homeostasis that makes bones fragile and more likely to break is an age-related disease called osteoporosis. If orthopedic stem cell treatment is not done on time, Osteoporosis can spread without a warning until there's a fracture in the hip, spine and wrist. Multipotent mesenchymal stem cells are the direct source of osteogenic regeneration. MSCs have osteogenic power and can repair and maintain the skeleton, hence, they are good for tissue engineering and regenerative purposes. Rheumatoid arthritis
This is a prolonged auto-immune inflammatory disease with dominant joint disease of corrosive advancing polyarthritis type. The pathogenesis basis of rheumatoid arthritis contains predetermined auto-immune processes that are inherited caused by deficit of T- suppressor function of lymphocytes. MSCs also show zero immunosuppressive properties, which suppress local inflammation and tissue damage in inflammatory autoimmune diseases. Autologous stem cells derived from bone marrow or adipose tissue induce the production of T regulatory cells, an immune cell that protects the body against immunological self-attack.
Avascular necrosis, also known as osteonecrosis, aseptic necrosis and ischemic bone necrosis, is a disease resulting from loss of blood supply to the bones. The bone tissue dies and leads to bone collapse due to the lack of blood. Mesenchymal stem cells from adult bone marrow are multipotent that can mould into fibroblastic, osteogenic, myogenic, adipogenic and reticular cells providing bone repair. Stem cell transplantation into the core pressure places renews dead area by the alteration process of stem cells into the bone cells. In stem cell treatment of AVN, patient undergoes surgery for joint replacement and even after that patient has restricted movements.
Stem cell therapy enriched with a bone-regenerating hormone, insulin-like growth factor-I (IGF-I), can help mend broken bones in fractures that are not healing normally. This problem is even more serious in children with osteogenesis imperfecta, or brittle bone disease, and in elderly adults with osteoporosis, because their fragile bones can easily and repeatedly break. Fractures that do not heal within the normal timeframe are called non-union fractures. It is found that the stem cells with high IGF-I became bone cells and helped the cells in the broken bones to repair the fracture, enhancing the healing.
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