Stem Cells are identical biological cells, which can make different specialized cells and can split to create more Stem Cells. They are easily found in multi-cellular organisms. In full grown organisms, Stem Cells work to mend the body system, restocking adult tissues. Adult Stem Cells are normally used in medical therapies, for example in bone marrow transplantation. Stem Cells can now be artificially grown and changed into specific cell kind with features dependable on cells of various tissues such as muscles or nerves.
Stem cells that reconstitute all types of blood cells treat a number of fatal diseases. Experiments show that the transfer of haematopoietic stem cells can overturn autoimmunity. Most patients with autoimmune disease have normal life expectancy though some suffer severe autoimmunity. Haematopoietic-cell transplantation (HCT) is a potential therapy for people with such severe intractable diseases. HCT involves the administration of haematopoietic stem cells (HSC), which are self-renewing and capable of giving rise to all mature haematopoietic cell types and possibly to some non-haematopoietic cell types. The patient is made ready for transplant by potent immunosuppressive treatment generally using chemotherapy or radiotherapy. Then autologous haematopoietic cells or allogeneic haematopoietic cells are transferred to restore the host immune system. Autoimmune disease can be cured by this procedure.
Indications:-
Diabetes Mellitus is one of the widespread hormonal diseases. This disease is noted by high blood sugar level ensuing from inadequate insulin creation in the body (type I diabetes) or body cells' inappropriate reaction to the formed insulin (type II diabetes). Stem cell treatment of diabetes can be done at all stages; However, it is most useful for new-onset insulin-dependent Diabetes Mellitus; Diabetes Mellitus complicated by diabetic glomerulosclerosis, chronic renal failure and anaemic disease; changeable course of diabetes mellitus; Diabetes Mellitus coupled with infections and lack of immunity; and presence of untreatable soft tissue trophic ulcers. Some major effects of Diabetes Mellitus treatment with stem cells are lessening glycemia in patients with new-onset insulin-dependent diabetes mellitus, syndrome of the early post-transplantation developments, upgrading of psychological and physiological conditions, rebuilding immunity and so on.
Muscular Dystrophy is a passive autosomal hereditary disorder that makes the muscles, which are responsible for the movement of the body, weak. A person who has muscular dystrophy is unable to produce dystrophin protein, which is essential for muscle fibre. Lack of dystrophin may result in gradual destruction of muscle over a time period. Stem cell treatment for muscular dystrophy uses medications that are generally designed to help reduce symptoms of muscle spasms, muscle weakness and stiffness. Stem cell treatment for Muscular Dystrophy: The Autologous stem cells are recognized to have myogenic differentiation characters. When these cells are grown in the lab they develop the ability to distinguish into muscle cells and self restore to maintain the muscle-forming stem cell pool. After stem cells are transplanted, they live, grow and travel to damaged-skeletal muscle.
Autism is a range of disorders with discernible abnormalities in communication and social interactions. Recent stem cell therapies for autism are efforts to annul these abnormalities through antibiotics, anti-inflammatory agents and hyperbaric oxygen. Sadly, none of these approaches tackle the real cause of oxygen deprivation and intestinal inflammation. Mesenchymal stem cells can control the immune system and help to reverse inflammatory conditions. Stem Cell Therapy for Autism through mesenchymal stem cells, have shown improvement in patients. Stem cells are intravenously administered or might also be administered intrathecally (into the spinal fluid), depending upon the age and physical size of the patient. Intrathecal injection allows the stem cells to bypass the blood-brain barrier and migrate throughout the central nervous system.
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